Vinesauce is HOPE, or Variety is HOPE, was a series of annual charity streams from 2018 to 2021 hosted by Vinesauce to raise money and awareness for the Pediatric Cancer Research Foundation (PCRF) in Irvine, California. The PCRF was founded in 1982 to support children and their families affected by pediatric cancer. The charity events were discontinued from 2023 onwards due to the large amount of effort to organize and one of the main organizers Hootey being busy with parental commitments instead.